Toxicologie IndustrielleEcologie (ERE)

FISA ERE Semester 10 Risk Engineering and Governance Option Machine translation

Industrial Toxicology

Teaching unit Ecology · ERE10IGR_ECO

5ECTS (EU)

1Coefficient

16:00Hours

Séquencement

Learning objectives

• Know the main metabolic pathways, modes of action and pathways of toxics into the body. • Use the physicochemical parameters of the SDS to anticipate the effects of toxic substances on the body and their modes of action • Decrypt SDS toxicological data

Prerequisites

Module	Teaching unit	Semester
Biology - Biochemistry - Anatomy	Sciences for Risk Governance	S8

Program

Introduction.

Definitions
General

Absorption, Distribution, Metabolism and Elimination

Toxic effects

A Toxic Effect: Factors, Mechanisms of Action
Diversity of toxic effects: local tolerance, sensitization/allergic, neurotoxicity, hepatotoxicity, carcinogenicity, mutagenesis, reproductive toxicity...
Dose-response relationship

Toxicity assessment and relationship to substance classification

Reference values

VTR, VLEP, Biological values
NOAEL, DNEL

Sources of Toxicology Information

Assessment

Table Control (Duration 1h30)

References

Industrial toxicology and occupational poisoning - Robert R. Lauwerys, Dominique Lison - 2007 Toxicology elements – Alain Viala – 1998 Occupational and Environmental Toxic Pathology – François Testud- 2005

Skills

Ref.	Verb	Description	Level
C6	analyze	Identify processes, equipment or technologies and their critical aspects. Evaluate process performance. Assess "a priori" related risks and propose possible prevention and/or protection actions	3